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Dokumenttyp:
journal article 
Autor(en):
Roth, Susanne; Rottach, Andrea; Lotz-Havla, Amelie S; Laux, Verena; Muschaweckh, Andreas; Gersting, Søren W; Muntau, Ania C; Hopfner, Karl-Peter; Jin, Lei; Vanness, Katelynd; Petrini, John H J; Drexler, Ingo; Leonhardt, Heinrich; Ruland, Jürgen 
Titel:
Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1? production. 
Abstract:
Double-stranded DNA (dsDNA) in the cytoplasm triggers the production of interleukin 1? (IL-1?) as an antiviral host response, and deregulation of the pathways involved can promote inflammatory disease. Here we report a direct cytosolic interaction between the DNA-damage sensor Rad50 and the innate immune system adaptor CARD9. Transfection of dendritic cells with dsDNA or infection of dendritic cells with a DNA virus induced the formation of dsDNA-Rad50-CARD9 signaling complexes for activation of...    »
 
Zeitschriftentitel:
Nat Immunol 
Jahr:
2014 
Band / Volume:
15 
Heft / Issue:
Seitenangaben Beitrag:
538-45 
Sprache:
eng 
Print-ISSN:
1529-2908 
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie