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Document type:
journal article 
Author(s):
Semper, Raphaela P; Mejías-Luque, Raquel; Groß, Christina; Anderl, Florian; Müller, Anne; Vieth, Michael; Busch, Dirk H; Prazeres da Costa, Clarissa; Ruland, Jürgen; Groß, Olaf; Gerhard, Markus 
Title:
Helicobacter pylori-induced IL-1? secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island. 
Abstract:
Infection with the gram-negative bacterium Helicobacter pylori is the most prevalent chronic bacterial infection, affecting ~50% of the world's population, and is the main risk factor of gastric cancer. The proinflammatory cytokine IL-1? plays a crucial role in the development of gastric tumors and polymorphisms in the IL-1 gene cluster leading to increased IL-1? production have been associated with increased risk for gastric cancer. To be active, pro-IL-1? must be cleaved by the inflammasome, a...    »
 
Journal title abbreviation:
J Immunol 
Year:
2014 
Journal volume:
193 
Journal issue:
Pages contribution:
3566-76 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Klinische Chemie und Pathobiochemie