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Dokumenttyp:
journal article 
Autor(en):
Bach, Martina P; Hug, Eva; Werner, Markus; Holch, Julian; Sprissler, Clara; Pechloff, Konstanze; Zirlik, Katja; Zeiser, Robert; Dierks, Christine; Ruland, Jürgen; Jumaa, Hassan 
Titel:
Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk. 
Abstract:
The development of hematopoietic neoplasms is often associated with mutations, altered gene expression or chromosomal translocations. Recently, the t(5, 9)(q33; q22) translocation was found in a subset of peripheral T cell lymphomas and was shown to result in an IL-2-inducible kinase-spleen tyrosine kinase (ITK-Syk) fusion transcript. In this study, we show that T cell-specific expression of the ITK-Syk oncogene in mice leads to an early onset and aggressive polyclonal T cell lymphoproliferation...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2014 
Band / Volume:
192 
Heft / Issue:
Seitenangaben Beitrag:
1024-33 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie