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Dokumenttyp:
journal article 
Autor(en):
Ruland, Jürgen 
Titel:
Inflammasome: putting the pieces together. 
Abstract:
Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine production and represent a unified mechanism for inflammasome assembly. 
Zeitschriftentitel:
Cell 
Jahr:
2014 
Band / Volume:
156 
Heft / Issue:
Seitenangaben Beitrag:
1127-9 
Sprache:
eng 
Print-ISSN:
0092-8674 
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie