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Dokumenttyp:
journal article 
Autor(en):
Hojer, Caroline; Frankenberger, Samantha; Strobl, Lothar J; Feicht, Samantha; Djermanovic, Kristina; Jagdhuber, Franziska; Hömig-Hölzel, Cornelia; Ferch, Uta; Ruland, Jürgen; Rajewsky, Klaus; Zimber-Strobl, Ursula 
Titel:
B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19. 
Abstract:
CD40, a member of the TNF receptor family, is expressed on all mature B cells and on most B-cell lymphomas. Recently, we have shown that constitutive activation of CD40 signaling in B cells induced by a fusion protein consisting of the transmembrane part of the Epstein-Barr viral latent membrane protein 1 (LMP1) and the cytoplasmic part of CD40 (LMP1/CD40) drives B-cell lymphoma development in transgenic mice. Because LMP1/CD40-expressing B cells showed an upregulation of CD19, we investigated C...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2014 
Band / Volume:
74 
Heft / Issue:
16 
Seitenangaben Beitrag:
4318-28 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie