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Document type:
journal article 
Author(s):
Hojer, Caroline; Frankenberger, Samantha; Strobl, Lothar J; Feicht, Samantha; Djermanovic, Kristina; Jagdhuber, Franziska; Hömig-Hölzel, Cornelia; Ferch, Uta; Ruland, Jürgen; Rajewsky, Klaus; Zimber-Strobl, Ursula 
Title:
B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19. 
Abstract:
CD40, a member of the TNF receptor family, is expressed on all mature B cells and on most B-cell lymphomas. Recently, we have shown that constitutive activation of CD40 signaling in B cells induced by a fusion protein consisting of the transmembrane part of the Epstein-Barr viral latent membrane protein 1 (LMP1) and the cytoplasmic part of CD40 (LMP1/CD40) drives B-cell lymphoma development in transgenic mice. Because LMP1/CD40-expressing B cells showed an upregulation of CD19, we investigated C...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2014 
Journal volume:
74 
Journal issue:
16 
Pages contribution:
4318-28 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie