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Document type:
journal article 
Author(s):
Khegai, O; Schulte, R F; Janich, M A; Menzel, M I; Farrell, E; Otto, A M; Ardenkjaer-Larsen, J H; Glaser, S J; Haase, A; Schwaiger, M; Wiesinger, F 
Title:
Apparent rate constant mapping using hyperpolarized [1-(13)C]pyruvate. 
Abstract:
Hyperpolarization of [1-13C]pyruvate in solution allows real-time measurement of uptake and metabolism using MR spectroscopic methods. After injection and perfusion, pyruvate is taken up by the cells and enzymatically metabolized into downstream metabolites such as lactate, alanine, and bicarbonate. In this work, we present comprehensive methods for the quantification and interpretation of hyperpolarized 13C metabolite signals. First, a time-domain spectral fitting method is described for the de...    »
 
Journal title abbreviation:
NMR Biomed 
Year:
2014 
Journal volume:
27 
Journal issue:
10 
Pages contribution:
1256-65 
Language:
eng 
Print-ISSN:
0952-3480 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik