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Document type:
journal article 
Author(s):
Soehngen, Eric; Schaefer, Andrea; Koeritzer, Julia; Huelsmeyer, Velia; Zimmer, Claus; Ringel, Florian; Gempt, Jens; Schlegel, Juergen 
Title:
Hypoxia upregulates aldehyde dehydrogenase isoform 1 (ALDH1) expression and induces functional stem cell characteristics in human glioblastoma cells. 
Abstract:
Aldehyde dehydrogenase 1 (ALDH1) has been used to isolate tumorigenic stem-like cells in a large number of tumors, including glioblastoma multiforme (GBM). We recently showed that human glioblastoma cells with high ALDH1 (ALDH1(high)) activity contain stem-cell-like characteristics. In the study reported here, we isolated established and primary human glioblastoma cells based on their ALDH1 expression. When tested for asymmetric division, only cells with ALDH1(high) expression were able to resto...    »
 
Journal title abbreviation:
Brain Tumor Pathol 
Year:
2014 
Journal volume:
31 
Journal issue:
Pages contribution:
247-56 
Language:
eng 
Print-ISSN:
1433-7398 
TUM Institution:
Abteilung für Neuroradiologie; Neurochirurgische Klinik und Poliklinik