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Dokumenttyp:
journal article 
Autor(en):
Neuhofer, Wolfgang, W; Küper, Christoph, C; Lichtnekert, Julia, J; Holzapfel, Konstantin, K; Rupanagudi, Khader V, KV; Fraek, Maria-Luisa, ML; Bartels, Helmut, H; Beck, Franz-Xaver, FX 
Titel:
Focal adhesion kinase regulates the activity of the osmosensitive transcription factor TonEBP/NFAT5 under hypertonic conditions. 
Abstract:
TonEBP/NFAT5 is a major regulator of the urinary concentrating process and is essential for the osmoadaptation of renal medullary cells. Focal adhesion kinase (FAK) is a mechanosensitive non-receptor protein tyrosine kinase expressed abundantly in the renal medulla. Since osmotic stress causes cell shrinkage, the present study investigated the contribution of FAK on TonEBP/NFAT5 activation. Osmotic stress induced time-dependent activation of FAK as evidenced by phosphorylation at Tyr-397, and fu...    »
 
Zeitschriftentitel:
Front Physiol 
Jahr:
2014 
Band / Volume:
Seitenangaben Beitrag:
123 
Sprache:
eng 
TUM Einrichtung:
r Radiologie