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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Klupp, Elisabeth; Forster, Stefan; Grimmer, Timo; Tahmasian, Masoud; Yakushev, Igor; Sorg, Christian; Yousefi, Behrooz H; Drzezga, Alexander 
Title:
In Alzheimer's disease, hypometabolism in low-amyloid brain regions may be a functional consequence of pathologies in connected brain regions. 
Abstract:
In patients with Alzheimer's disease (AD), prominent hypometabolism has been observed in brain regions with minor amyloid load. These hypometabolism-only (HO) areas cannot be explained merely as a consequence of local amyloid toxicity. The aim of this multimodal imaging study was to explore whether such HO phenomenon may be related to pathologies in functionally connected, remote brain regions. Nineteen AD patients and 15 matched controls underwent examinations with [(11)C]PiB-PET and [(18)F]FDG...    »
 
Journal title abbreviation:
Brain Connect 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
371-83 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
2158-0014 
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie