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Dokumenttyp:
journal article 
Autor(en):
Wohrer, Stefan; Knapp, David J H F; Copley, Michael R; Benz, Claudia; Kent, David G; Rowe, Keegan; Babovic, Sonja; Mader, Heidi; Oostendorp, Robert A J; Eaves, Connie J 
Titel:
Distinct stromal cell factor combinations can separately control hematopoietic stem cell survival, proliferation, and self-renewal. 
Abstract:
Hematopoietic stem cells (HSCs) are identified by their ability to sustain prolonged blood cell production in vivo, although recent evidence suggests that durable self-renewal (DSR) is shared by HSC subtypes with distinct self-perpetuating differentiation programs. Net expansions of DSR-HSCs occur in vivo, but molecularly defined conditions that support similar responses in vitro are lacking. We hypothesized that this might require a combination of factors that differentially promote HSC viabili...    »
 
Zeitschriftentitel:
Cell Rep 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
1956-67 
Sprache:
eng 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik