Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Dechow, Tobias; Steidle, Sabine; Götze, Katharina S; Rudelius, Martina; Behnke, Kerstin; Pechloff, Konstanze; Kratzat, Susanne; Bullinger, Lars; Fend, Falko; Soberon, Valeria; Mitova, Nadya; Li, Zhoulei; Thaler, Markus; Bauer, Jan; Pietschmann, Elke; Albers, Corinna; Grundler, Rebekka; Schmidt-Supprian, Marc; Ruland, Jürgen; Peschel, Christian; Duyster, Justus; Rose-John, Stefan; Bassermann, Florian; Keller, Ulrich 
Titel:
GP130 activation induces myeloma and collaborates with MYC. 
Abstract:
Multiple myeloma (MM) is a plasma cell neoplasm that results from clonal expansion of an Ig-secreting terminally differentiated B cell. Advanced MM is characterized by tissue damage that involves bone, kidney, and other organs and is typically associated with recurrent genetic abnormalities. IL-6 signaling via the IL-6 signal transducer GP130 has been implicated as an important driver of MM pathogenesis. Here, we demonstrated that ectopic expression of constitutively active GP130 (L-GP130) in a...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2014 
Band / Volume:
124 
Heft / Issue:
12 
Seitenangaben Beitrag:
5263-74 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; Institut für Klinische Chemie und Pathobiochemie