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Document type:
journal article 
Author(s):
Heger, Klaus; Fierens, Kaat; Vahl, J Christoph; Aszodi, Attila; Peschke, Katrin; Schenten, Dominik; Hammad, Hamida; Beyaert, Rudi; Saur, Dieter; van Loo, Geert; Roers, Axel; Lambrecht, Bart N; Kool, Mirjam; Schmidt-Supprian, Marc 
Title:
A20-deficient mast cells exacerbate inflammatory responses in vivo. 
Abstract:
Mast cells are implicated in the pathogenesis of inflammatory and autoimmune diseases. However, this notion based on studies in mast cell-deficient mice is controversial. We therefore established an in vivo model for hyperactive mast cells by specifically ablating the NF-?B negative feedback regulator A20. While A20 deficiency did not affect mast cell degranulation, it resulted in amplified pro-inflammatory responses downstream of IgE/Fc?RI, TLRs, IL-1R, and IL-33R. As a consequence house dust m...    »
 
Journal title abbreviation:
PLoS Biol 
Year:
2014 
Journal volume:
12 
Journal issue:
Pages contribution:
e1001762 
Language:
eng 
Print-ISSN:
1544-9173 
TUM Institution:
II. Medizinische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik