User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Heger, Klaus; Seidler, Barbara; Vahl, J Christoph; Schwartz, Christian; Kober, Maike; Klein, Sabine; Voehringer, David; Saur, Dieter; Schmidt-Supprian, Marc 
Title:
CreER(T2) expression from within the c-Kit gene locus allows efficient inducible gene targeting in and ablation of mast cells. 
Abstract:
Mast cells are abundantly situated at contact sites between the body and its environment, such as the skin and, especially during certain immune responses, at mucosal surfaces. They mediate allergic reactions and degrade toxins as well as venoms. However, their roles during innate and adaptive immune responses remain controversial and it is likely that major functions remain to be discovered. Recent developments in mast cell-specific conditional gene targeting in the mouse promise to enhance our...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2014 
Journal volume:
44 
Journal issue:
Pages contribution:
296-306 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0014-2980 
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)