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Dokumenttyp:
journal article 
Autor(en):
Heger, Klaus; Seidler, Barbara; Vahl, J Christoph; Schwartz, Christian; Kober, Maike; Klein, Sabine; Voehringer, David; Saur, Dieter; Schmidt-Supprian, Marc 
Titel:
CreER(T2) expression from within the c-Kit gene locus allows efficient inducible gene targeting in and ablation of mast cells. 
Abstract:
Mast cells are abundantly situated at contact sites between the body and its environment, such as the skin and, especially during certain immune responses, at mucosal surfaces. They mediate allergic reactions and degrade toxins as well as venoms. However, their roles during innate and adaptive immune responses remain controversial and it is likely that major functions remain to be discovered. Recent developments in mast cell-specific conditional gene targeting in the mouse promise to enhance our...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2014 
Band / Volume:
44 
Heft / Issue:
Seitenangaben Beitrag:
296-306 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik