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Document type:
journal article 
Author(s):
Balic, Anamaria; Sørensen, Morten Dræby; Trabulo, Sara Maria; Sainz, Bruno; Cioffi, Michele; Vieira, Catarina R; Miranda-Lorenzo, Irene; Hidalgo, Manuel; Kleeff, Joerg; Erkan, Mert; Heeschen, Christopher 
Title:
Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. 
Abstract:
Pancreatic ductal adenocarcinoma is one of the deadliest carcinomas and is characterized by highly tumorigenic and metastatic cancer stem cells (CSC). CSCs evade available therapies, which preferentially target highly proliferative and more differentiated progenies, leaving behind CSCs as a putative source for disease relapse. Thus, to identify potentially more effective treatment regimens, we screened established and new compounds for their ability to eliminate CSCs in primary pancreatic cancer...    »
 
Journal title abbreviation:
Mol Cancer Ther 
Year:
2014 
Journal volume:
13 
Journal issue:
Pages contribution:
1758-71 
Language:
eng 
Print-ISSN:
1535-7163 
TUM Institution:
Chirurgiesche Klinik und Poliklinik