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Document type:
journal article 
Author(s):
Roepman, Paul; Schlicker, Andreas; Tabernero, Josep; Majewski, Ian; Tian, Sun; Moreno, Victor; Snel, Mireille H; Chresta, Christine M; Rosenberg, Robert; Nitsche, Ulrich; Macarulla, Teresa; Capella, Gabriel; Salazar, Ramon; Orphanides, George; Wessels, Lodewyk F A; Bernards, Rene; Simon, Iris M 
Title:
Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition. 
Abstract:
In most colorectal cancer (CRC) patients, outcome cannot be predicted because tumors with similar clinicopathological features can have differences in disease progression and treatment response. Therefore, a better understanding of the CRC biology is required to identify those patients who will benefit from chemotherapy and to find a more tailored therapy plan for other patients. Based on unsupervised classification of whole genome data from 188 stages I-IV CRC patients, a molecular classificati...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2014 
Journal volume:
134 
Journal issue:
Pages contribution:
552-62 
Language:
eng 
Print-ISSN:
0020-7136 
TUM Institution:
Chirurgiesche Klinik und Poliklinik