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Document type:
journal article 
Author(s):
Yalçin, Serap; Erkan, Mert; Ünsoy, Gözde; Parsian, Maryam; Kleeff, Jörg; Gündüz, Ufuk 
Title:
Effect of gemcitabine and retinoic acid loaded PAMAM dendrimer-coated magnetic nanoparticles on pancreatic cancer and stellate cell lines. 
Abstract:
Gemcitabine is an anticancer drug used in the treatment of different cancer types, including pancreatic ductal adenocarcinoma. The maximum tolerated dose in humans is restricted by its side effects on healty cells. Furthermore, the fibrotic stroma produced by the pancreatic stellate cells prevents effective delivery of chemotherapeutic agents providing a safe-haven for the cancer cells. This becomes more of a problem considering the short half-life of this drug. Magnetic nanoparticle-based targe...    »
 
Journal title abbreviation:
Biomed Pharmacother 
Year:
2014 
Journal volume:
68 
Journal issue:
Pages contribution:
737-43 
Language:
eng 
Print-ISSN:
0753-3322 
TUM Institution:
Chirurgiesche Klinik und Poliklinik