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Dokumenttyp:
journal article 
Autor(en):
Miranda-Lorenzo, Irene; Dorado, Jorge; Lonardo, Enza; Alcala, Sonia; Serrano, Alicia G; Clausell-Tormos, Jenifer; Cioffi, Michele; Megias, Diego; Zagorac, Sladjana; Balic, Anamaria; Hidalgo, Manuel; Erkan, Mert; Kleeff, Joerg; Scarpa, Aldo; Sainz, Bruno; Heeschen, Christopher 
Titel:
Intracellular autofluorescence: a biomarker for epithelial cancer stem cells. 
Abstract:
Cancer stem cells (CSCs) are thought to drive tumor growth, metastasis and chemoresistance. Although surface markers such as CD133 and CD44 have been successfully used to isolate CSCs, their expression is not exclusively linked to the CSC phenotype and is prone to environmental alteration. We identified cells with an autofluorescent subcellular compartment that exclusively showed CSC features across different human tumor types. Primary tumor-derived autofluorescent cells did not overlap with sid...    »
 
Zeitschriftentitel:
Nat Methods 
Jahr:
2014 
Band / Volume:
11 
Heft / Issue:
11 
Seitenangaben Beitrag:
1161-9 
Sprache:
eng 
Print-ISSN:
1548-7091 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik