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Dokumenttyp:
journal article 
Autor(en):
Stilgenbauer, Stephan; Schnaiter, Andrea; Paschka, Peter; Zenz, Thorsten; Rossi, Marianna; Döhner, Konstanze; Bühler, Andreas; Böttcher, Sebastian; Ritgen, Matthias; Kneba, Michael; Winkler, Dirk; Tausch, Eugen; Hoth, Patrick; Edelmann, Jennifer; Mertens, Daniel; Bullinger, Lars; Bergmann, Manuela; Kless, Sabrina; Mack, Silja; Jäger, Ulrich; Patten, Nancy; Wu, Lin; Wenger, Michael K; Fingerle-Rowson, Günter; Lichter, Peter; Cazzola, Mario; Wendtner, Clemens M; Fink, Anna M; Fischer, Kirsten; Bus...    »
 
Titel:
Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial. 
Abstract:
Mutations in TP53, NOTCH1, and SF3B1 were analyzed in the CLL8 study evaluating first-line therapy with fludarabine and cyclophosphamide (FC) or FC with rituximab (FCR) among patients with untreated chronic lymphocytic leukemia (CLL). TP53, NOTCH1, and SF3B1 were mutated in 11.5%, 10.0%, and 18.4% of patients, respectively. NOTCH1(mut) and SF3B1(mut) virtually showed mutual exclusivity (0.6% concurrence), but TP53(mut) was frequently found in NOTCH1(mut) (16.1%) and in SF3B1(mut) (14.0%) patient...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2014 
Band / Volume:
123 
Heft / Issue:
21 
Seitenangaben Beitrag:
3247-54 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie