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Document type:
journal article 
Author(s):
Kamp, F; Brüningk, S; Cabal, G; Mairani, A; Parodi, K; Wilkens, J J 
Title:
Variance-based sensitivity analysis of biological uncertainties in carbon ion therapy. 
Abstract:
Biological models to estimate the relative biological effectiveness (RBE) or the equivalent dose in 2 Gy fractions (EQD2) are needed for treatment planning and plan evaluation in carbon ion therapy. We present a model-independent, Monte Carlo based sensitivity analysis (SA) approach to quantify the impact of different uncertainties on the biological models.The Monte Carlo based SA is used for the evaluation of variations in biological parameters. The key property of this SA is the high number of...    »
 
Journal title abbreviation:
Phys Med 
Year:
2014 
Journal volume:
30 
Journal issue:
Pages contribution:
583-7 
Language:
eng 
Print-ISSN:
1120-1797 
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie