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Dokumenttyp:
journal article 
Autor(en):
Wick, Wolfgang; Fricke, Harald; Junge, Klaus; Kobyakov, Grigory; Martens, Tobias; Heese, Oliver; Wiestler, Benedikt; Schliesser, Maximilian G; von Deimling, Andreas; Pichler, Josef; Vetlova, Elena; Harting, Inga; Debus, Jürgen; Hartmann, Christian; Kunz, Claudia; Platten, Michael; Bendszus, Martin; Combs, Stephanie E 
Titel:
A phase II, randomized, study of weekly APG101+reirradiation versus reirradiation in progressive glioblastoma. 
Abstract:
Preclinical data indicate anti-invasive activity of APG101, a CD95 ligand (CD95L)-binding fusion protein, in glioblastoma.Patients (N = 91) with glioblastoma at first or second progression were randomized 1:2 between second radiotherapy (rRT; 36 Gy; five times 2 Gy per week) or rRT+APG101 (400 mg weekly i.v.). Patient characteristics [N = 84 (26 patients rRT, 58 patients rRT+APG101)] were balanced.Progression-free survival at 6 months (PFS-6) rates were 3.8% [95% confidence interval (CI), 0.1-...    »
 
Zeitschriftentitel:
Clin Cancer Res 
Jahr:
2014 
Band / Volume:
20 
Heft / Issue:
24 
Seitenangaben Beitrag:
6304-13 
Sprache:
eng 
Print-ISSN:
1078-0432 
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie