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Document type:
journal article 
Author(s):
Bayer, Christine; Liebhardt, Michael E; Schmid, Thomas E; Trajkovic-Arsic, Marija; Hube, Kathrin; Specht, Hanno M; Schilling, Daniela; Gehrmann, Mathias; Stangl, Stefan; Siveke, Jens T; Wilkens, Jan J; Multhoff, Gabriele 
Title:
Validation of heat shock protein 70 as a tumor-specific biomarker for monitoring the outcome of radiation therapy in tumor mouse models. 
Abstract:
Tumor cells, in contrast to normal cells, frequently overexpress heat shock protein 70 (Hsp70) in the cytosol, present it on their cell surface, and actively release it. Therefore, soluble Hsp70 (sHsp70) was investigated as a potential tumor biomarker for monitoring the outcome of radiation therapy.Plasma from mice bearing membrane Hsp70 (mHsp70)-positive FaDu human squamous cell carcinoma of the head and neck and spontaneous pancreatic ductal adenocarcinoma (PDAC) was investigated. A cohort of...    »
 
Journal title abbreviation:
Int J Radiat Oncol Biol Phys 
Year:
2014 
Journal volume:
88 
Journal issue:
Pages contribution:
694-700 
Language:
eng 
Print-ISSN:
0360-3016 
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie