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Document type:
journal article 
Author(s):
Gehrmann, Mathias; Stangl, Stefan; Foulds, Gemma A; Oellinger, Rupert; Breuninger, Stephanie; Rad, Roland; Pockley, Alan G; Multhoff, Gabriele 
Title:
Tumor imaging and targeting potential of an Hsp70-derived 14-mer peptide. 
Abstract:
We have previously used a unique mouse monoclonal antibody cmHsp70.1 to demonstrate the selective presence of a membrane-bound form of Hsp70 (memHsp70) on a variety of leukemia cells and on single cell suspensions derived from solid tumors of different entities, but not on non-transformed cells or cells from corresponding'healthy' tissue. This antibody can be used to image tumors in vivo and target them for antibody-dependent cellular cytotoxicity. Tumor-specific expression of memHsp70 therefore...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
e105344 
Language:
eng 
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; II. Medizinische Klinik und Poliklinik