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Dokumenttyp:
journal article 
Autor(en):
Sunami, Yoshiaki; von Figura, Guido; Kleger, Alexander; Strnad, Pavel; Hüser, Norbert; Hartmann, Daniel 
Titel:
The role of telomeres in liver disease. 
Abstract:
Telomeres stabilize open chromosome ends and protect them against chromosomal end-to-end fusions, breakage, instability, and nonreciprocal translocations. Telomere dysfunction is known to lead to an impaired regenerative capacity of hepatocytes and an increased cirrhosis formation in the context of acute and chronic liver injury. In addition, telomere dysfunction and telomerase mutations have been associated with the induction of chromosomal instability and consequently with cirrhosis developmen...    »
 
Zeitschriftentitel:
Prog Mol Biol Transl Sci 
Jahr:
2014 
Band / Volume:
125 
Seitenangaben Beitrag:
159-72 
Sprache:
eng 
Print-ISSN:
1877-1173 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik