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Document type:
journal article 
Author(s):
Sunami, Yoshiaki; von Figura, Guido; Kleger, Alexander; Strnad, Pavel; Hüser, Norbert; Hartmann, Daniel 
Title:
The role of telomeres in liver disease. 
Abstract:
Telomeres stabilize open chromosome ends and protect them against chromosomal end-to-end fusions, breakage, instability, and nonreciprocal translocations. Telomere dysfunction is known to lead to an impaired regenerative capacity of hepatocytes and an increased cirrhosis formation in the context of acute and chronic liver injury. In addition, telomere dysfunction and telomerase mutations have been associated with the induction of chromosomal instability and consequently with cirrhosis developmen...    »
 
Journal title abbreviation:
Prog Mol Biol Transl Sci 
Year:
2014 
Journal volume:
125 
Pages contribution:
159-72 
Language:
eng 
Print-ISSN:
1877-1173 
TUM Institution:
Chirurgiesche Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik