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Document type:
journal article 
Author(s):
Hackstein, Carl-Philipp; Assmus, Lisa Mareike; Welz, Meike; Klein, Sabine; Schwandt, Timo; Schultze, Joachim; Förster, Irmgard; Gondorf, Fabian; Beyer, Marc; Kroy, Daniela; Kurts, Christian; Trebicka, Jonel; Kastenmüller, Wolfgang; Knolle, Percy A; Abdullah, Zeinab 
Title:
Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. 
Abstract:
Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity.Experimental liver fibrosis in mice induced by bile duct ligation or CCl application was used to characterise the mechanisms determining failure of innate immunity to control bacterial infections.In murine liver fibrosis, translocation of gut microbiota induced tonic type I interferon (IFN) expression in the liver. Such tonic IFN expression conditioned live...    »
 
Journal title abbreviation:
Gut 
Year:
2017 
Journal volume:
66 
Journal issue:
Pages contribution:
507-518 
Language:
eng 
Print-ISSN:
0017-5749 
TUM Institution:
Institut für Molekulare Immunologie