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Document type:
journal article 
Author(s):
Heuser, Christoph; Gotot, Janine; Piotrowski, Eveline Christina; Philipp, Marie-Sophie; Courrèges, Christina Johanna Felicia; Otte, Martin Sylvester; Guo, Linlin; Schmid-Burgk, Jonathan Leo; Hornung, Veit; Heine, Annkristin; Knolle, Percy Alexander; Garbi, Natalio; Serfling, Edgar; Evaristo, César; Thaiss, Friedrich; Kurts, Christian 
Title:
Prolonged IKK? Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells. 
Abstract:
Regulatory T cells (Tregs) prevent autoimmunity but limit antitumor immunity. The canonical NF-?B signaling pathway both activates immunity and promotes thymic Treg development. Here, we report that mature Tregs continue to require NF-?B signaling through I?B-kinase ? (IKK?) after thymic egress. Mice lacking IKK? in mature Tregs developed scurfy-like immunopathology due to death of peripheral FoxP3 Tregs. Also, pharmacological IKK? inhibition reduced Treg numbers in the circulation by ~50% and d...    »
 
Journal title abbreviation:
Cell Rep 
Year:
2017 
Journal volume:
21 
Journal issue:
Pages contribution:
578-586 
Language:
eng 
TUM Institution:
Institut für Molekulare Immunologie