User: Guest  Login
Document type:
journal article 
Author(s):
Herold, Martin; Breuer, Johanna; Hucke, Stephanie; Knolle, Percy; Schwab, Nicholas; Wiendl, Heinz; Klotz, Luisa 
Title:
Liver X receptor activation promotes differentiation of regulatory T cells. 
Abstract:
The nuclear receptor Liver X Receptor (LXR) is a ligand-activated transcription factor that has been implicated in control of chronic inflammation by downregulating pro-inflammatory T cell responses. An impaired function of regulatory T cells, a subset of CD4+ T cells with a crucial role in maintaining lymphocytes homeostasis and immune regulation, is frequently observed in chronic inflammatory diseases. We observed that pharmacological activation of LXR in T cells not only resulted in a thoroug...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2017 
Journal volume:
12 
Journal issue:
Pages contribution:
e0184985 
Language:
eng 
TUM Institution:
Institut für Molekulare Immunologie