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Document type:
journal article 
Author(s):
Volckmar, Julia; Gereke, Marcus; Ebensen, Thomas; Riese, Peggy; Philipsen, Lars; Lienenklaus, Stefan; Wohlleber, Dirk; Klopfleisch, Robert; Stegemann-Koniszewski, Sabine; Müller, Andreas J; Gruber, Achim D; Knolle, Percy; Guzman, Carlos A; Bruder, Dunja 
Title:
Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver. 
Abstract:
Hepatotropic viruses such as hepatitis C virus cause life-threatening chronic liver infections in millions of people worldwide. Targeted in vivo antigen-delivery to cross-presenting dendritic cells (DCs) has proven to be extraordinarily efficient in stimulating antigen-specific T cell responses. To determine whether this approach would as well be suitable to induce local antiviral effector T cells in the liver we compared different vaccine formulations based on either the targeting of DEC-205 or...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2017 
Journal volume:
Pages contribution:
43985 
Language:
eng 
TUM Institution:
Institut für Molekulare Immunologie