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Document type:
journal article 
Author(s):
Fang, HY; Hughes, R; Murdoch, C; Coffelt, SB; Biswas, SK; Harris, AL; Johnson, RS; Imityaz, HZ; Simon, MC; Fredlund, E; Greten, FR; Rius, J; Lewis, CE 
Title:
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. 
Abstract:
Ischemia exists in many diseased tissues, including arthritic joints, atherosclerotic plaques, and malignant tumors. Macrophages accumulate in these sites and up-regulate hypoxia-inducible transcription factors (HIFs) 1 and 2 in response to the hypoxia present. Here we show that the gene expression profile in primary human and murine macrophages changes markedly when they are exposed to hypoxia for 18 hours. For example, they were seen to up-regulate the cell surface receptors, CXCR4 and GLUT1,...    »
 
Journal title abbreviation:
Blood 
Year:
2009 
Journal volume:
114 
Journal issue:
Pages contribution:
844-59 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Molekulare Immunologie ; II. Medizinische Klinik und Poliklinik