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Document type:
journal article 
Author(s):
Stangl, Stefan; Varga, Julia; Freysoldt, Bianca; Trajkovic-Arsic, Marija; Siveke, Jens T; Greten, Florian R; Ntziachristos, Vasilis; Multhoff, Gabriele 
Title:
Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe. 
Abstract:
Although in vivo targeting of tumors using fluorescently labeled probes has greatly gained in importance over the last few years, most of the clinically applied reagents lack tumor cell specificity. Our novel tumor cell-penetrating peptide-based probe (TPP) recognizes an epitope of Hsp70 that is exclusively present on the cell surface of a broad variety of human and mouse tumors and metastases, but not on normal tissues. Because of the rapid turnover rate of membrane Hsp70, fluorescently labeled...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2014 
Journal volume:
74 
Journal issue:
23 
Pages contribution:
6903-12 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; II. Medizinische Klinik und Poliklinik; Lehrstuhl für Biologische Bildgebung