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Dokumenttyp:
journal article 
Autor(en):
Illert, Anna L; Seitz, Anna K; Rummelt, Christoph; Kreutmair, Stefanie; Engh, Richard A; Goodstal, Samantha; Peschel, Christian; Duyster, Justus; von Bubnoff, Nikolas 
Titel:
Inhibition of Aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases R763/AS703569 and PHA-739358 in BCR-ABL transformed cells. 
Abstract:
ABL tyrosine kinase inhibitors (TKI) like Imatinib, Dasatinib and Nilotinib are the gold standard in conventional treatment of CML. However, the emergence of resistance remains a major problem. Alternative therapeutic strategies of ABL TKI-resistant CML are urgently needed. We asked whether dual inhibition of BCR-ABL and Aurora kinases A-C could overcome resistance mediated by ABL kinase mutations. We therefore tested the dual ABL and Aurora kinase inhibitors PHA-739358 and R763/AS703569 in Ba/F...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2014 
Band / Volume:
Heft / Issue:
11 
Seitenangaben Beitrag:
e112318 
Sprache:
eng 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; Urologische Klinik und Poliklinik