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Dokumenttyp:
journal article 
Autor(en):
Loibl, Sibylle; von Minckwitz, Gunter; Schneeweiss, Andreas; Paepke, Stefan; Lehmann, Annika; Rezai, Mahdi; Zahm, Dirk M; Sinn, Peter; Khandan, Fariba; Eidtmann, Holger; Dohnal, Karel; Heinrichs, Clemens; Huober, Jens; Pfitzner, Berit; Fasching, Peter A; Andre, Fabrice; Lindner, Judith L; Sotiriou, Christos; Dykgers, August; Guo, Sanxing; Gade, Stephan; Nekljudova, Valentina; Loi, Sherene; Untch, Michael; Denkert, Carsten 
Titel:
PIK3CA mutations are associated with lower rates of pathologic complete response to anti-human epidermal growth factor receptor 2 (her2) therapy in primary HER2-overexpressing breast cancer. 
Abstract:
Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in breast cancer, with mutations in PIK3CA being the most common. This study investigated the association between PIK3CA genotype and pathologic complete response (pCR) rates in human epidermal growth factor receptor 2 (HER2)-positive breast cancer treated with either dual or single anti-HER2 treatment in addition to neoadjuvant chemotherapy.PIK3CA mutations in 504 tumor samples from participants in the neoadjuvant GeparQuat...    »
 
Zeitschriftentitel:
J Clin Oncol 
Jahr:
2014 
Band / Volume:
32 
Heft / Issue:
29 
Seitenangaben Beitrag:
3212-20 
Sprache:
eng 
Print-ISSN:
0732-183X 
TUM Einrichtung:
Frauenklinik und Poliklinik