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Dokumenttyp:
journal article 
Autor(en):
Shahinian, Hasmik; Loessner, Daniela; Biniossek, Martin L; Kizhakkedathu, Jayachandran N; Clements, Judith A; Magdolen, Viktor; Schilling, Oliver 
Titel:
Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGF?-1 signaling in ovarian cancer cells. 
Abstract:
Kallikrein-related peptidases, in particular KLK4, 5, 6 and 7 (4-7), often have elevated expression levels in ovarian cancer. In OV-MZ-6 ovarian cancer cells, combined expression of KLK4-7 reduces cell adhesion and increases cell invasion and resistance to paclitaxel. The present work investigates how KLK4-7 shape the secreted proteome ("secretome") and proteolytic profile ("degradome") of ovarian cancer cells. The secretome comparison consistently identified>900 proteins in three replicate anal...    »
 
Zeitschriftentitel:
Mol Oncol 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
68-82 
Sprache:
eng 
Print-ISSN:
1574-7891 
TUM Einrichtung:
Frauenklinik und Poliklinik