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Dokumenttyp:
journal article 
Autor(en):
Skala, Wolfgang; Utzschneider, Daniel T; Magdolen, Viktor; Debela, Mekdes; Guo, Shihui; Craik, Charles S; Brandstetter, Hans; Goettig, Peter 
Titel:
Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity. 
Abstract:
Human kallikrein-related peptidase 2 (KLK2) is a tryptic serine protease predominantly expressed in prostatic tissue and secreted into prostatic fluid, a major component of seminal fluid. Most likely it activates and complements chymotryptic KLK3 (prostate-specific antigen) in cleaving seminal clotting proteins, resulting in sperm liquefaction. KLK2 belongs to the "classical" KLKs 1-3, which share an extended 99- or kallikrein loop near their non-primed substrate binding site. Here, we report th...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2014 
Band / Volume:
289 
Heft / Issue:
49 
Seitenangaben Beitrag:
34267-83 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
Frauenklinik und Poliklinik