Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Müller, Martina A; Brunie, Leonora; Bächer, Anne-Sophie; Kessler, Horst; Gottschalk, Kay-Eberhard; Reuning, Ute 
Titel:
Cytoplasmic salt bridge formation in integrin ?vß3 stabilizes its inactive state affecting integrin-mediated cell biological effects. 
Abstract:
Heterodimeric integrin receptors are mediators of cell adhesion, motility, invasion, proliferation, and survival. By this, they are crucially involved in (tumor) cell biological behavior. Integrins trigger signals bidirectionally across cell membranes: by outside-in, following binding of protein ligands of the extracellular matrix, and by inside-out, where proteins are recruited to ß-integrin cytoplasmic tails resulting in conformational changes leading to increased integrin binding affinity and...    »
 
Zeitschriftentitel:
Cell Signal 
Jahr:
2014 
Band / Volume:
26 
Heft / Issue:
11 
Seitenangaben Beitrag:
2493-503 
Sprache:
eng 
Print-ISSN:
0898-6568 
TUM Einrichtung:
Frauenklinik und Poliklinik