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Dokumenttyp:
journal article 
Autor(en):
Kast, Karin; Schmutzler, Rita K; Rhiem, Kerstin; Kiechle, Marion; Fischer, Christine; Niederacher, Dieter; Arnold, Norbert; Grimm, Tiemo; Speiser, Dorothee; Schlegelberger, Brigitte; Varga, Dominic; Horvath, Judit; Beer, Marit; Briest, Susanne; Meindl, Alfons; Engel, Christoph 
Titel:
Validation of the Manchester scoring system for predicting BRCA1/2 mutations in 9,390 families suspected of having hereditary breast and ovarian cancer. 
Abstract:
The Manchester scoring system (MSS) allows the calculation of the probability for the presence of mutations in BRCA1 or BRCA2 genes in families suspected of having hereditary breast and ovarian cancer. In 9,390 families, we determined the predictive performance of the MSS without (MSS-2004) and with (MSS-2009) consideration of pathology parameters. Moreover, we validated a recalibrated version of the MSS-2009 (MSS-recal). Families were included in the registry of the German Consortium for Heredi...    »
 
Zeitschriftentitel:
Int J Cancer 
Jahr:
2014 
Band / Volume:
135 
Heft / Issue:
10 
Seitenangaben Beitrag:
2352-61 
Sprache:
eng 
Print-ISSN:
0020-7136 
TUM Einrichtung:
Frauenklinik und Poliklinik