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Dokumenttyp:
journal article 
Autor(en):
Purrington, Kristen S; Slettedahl, Seth; Bolla, Manjeet K; Michailidou, Kyriaki; Czene, Kamila; Nevanlinna, Heli; Bojesen, Stig E; Andrulis, Irene L; Cox, Angela; Hall, Per; Carpenter, Jane; Yannoukakos, Drakoulis; Haiman, Christopher A; Fasching, Peter A; Mannermaa, Arto; Winqvist, Robert; Brenner, Hermann; Lindblom, Annika; Chenevix-Trench, Georgia; Benitez, Javier; Swerdlow, Anthony; Kristensen, Vessela; Guénel, Pascal; Meindl, Alfons; Darabi, Hatef; Eriksson, Mikael; Fagerholm, Rainer; Aitto...    »
 
Titel:
Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade. 
Abstract:
Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (n = 39 067 cases; n = 42 106 controls). SNPs...    »
 
Zeitschriftentitel:
Hum Mol Genet 
Jahr:
2014 
Band / Volume:
23 
Heft / Issue:
22 
Seitenangaben Beitrag:
6034-46 
Sprache:
eng 
Print-ISSN:
0964-6906 
TUM Einrichtung:
Frauenklinik und Poliklinik