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Document type:
journal article 
Author(s):
Chiozzini, Chiara; Collacchi, Barbara; Nappi, Filomena; Bauer, Tanja; Arenaccio, Claudia; Tripiciano, Antonella; Longo, Olimpia; Ensoli, Fabrizio; Cafaro, Aurelio; Ensoli, Barbara; Federico, Maurizio 
Title:
Surface-bound Tat inhibits antigen-specific CD8+ T-cell activation in an integrin-dependent manner. 
Abstract:
The identification of still unrevealed mechanisms affecting the anti-HIV CD8 T-cell response in HIV-1 infection.Starting from the observation that anti-Tat immunization is associated with improved CD8 T-cell immunity, we developed both in-vitro and ex-vivo assays to characterize the effects of extra-cellular Tat on the adaptive CD8 T-cell response.The effects of Tat on CD8 T-cell activation were assayed using CD8 T-cell clones specific for either cellular (MART-1) or viral (HIV-1 Nef) antigens,...    »
 
Journal title abbreviation:
AIDS 
Year:
2014 
Journal volume:
28 
Journal issue:
15 
Pages contribution:
2189-200 
Language:
eng 
Print-ISSN:
0269-9370 
TUM Institution:
Institut für Virologie