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Document type:
journal article 
Author(s):
Kratzer, Stephan; Mattusch, Corinna; Metzger, Michael W; Dedic, Nina; Noll-Hussong, Michael; Kafitz, Karl W; Eder, Matthias; Deussing, Jan M; Holsboer, Florian; Kochs, Eberhard; Rammes, Gerhard 
Title:
Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels. 
Abstract:
Corticotropin-releasing hormone (CRH) plays an important role in a substantial number of patients with stress-related mental disorders, such as anxiety disorders and depression. CRH has been shown to increase neuronal excitability in the hippocampus, but the underlying mechanisms are poorly understood. The effects of CRH on neuronal excitability were investigated in acute hippocampal brain slices. Population spikes (PS) and field excitatory postsynaptic potentials (fEPSP) were evoked by stimulat...    »
 
Journal title abbreviation:
Front Cell Neurosci 
Year:
2013 
Journal volume:
Pages contribution:
91 
Language:
eng 
TUM Institution:
Klinik für Anästhesiologie