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Dokumenttyp:
journal article 
Autor(en):
Friedmann Angeli, Jose Pedro, JP; Schneider, Manuela, M; Proneth, Bettina, B; Tyurina, Yulia Y, YY; Tyurin, Vladimir A, VA; Hammond, Victoria J, VJ; Herbach, Nadja, N; Aichler, Michaela, M; Walch, Axel, A; Eggenhofer, Elke, E; Basavarajappa, Devaraj, D; Rådmark, Olof, O; Kobayashi, Sho, S; Seibt, Tobias, T; Beck, Heike, H; Neff, Frauke, F; Esposito, Irene, I; Wanke, Rüdiger, R; Förster, Heidi, H; Yefremova, Olena, O; Heinrichmeyer, Marc, M; Bornkamm, Georg W, GW; Geissler, Edward K, EK; Thomas,...    »
 
Titel:
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. 
Abstract:
Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in non-transformed cells and tissues is unexplored and remains enigmatic. Here, we provide direct genetic evidence that the knockout of glutathione peroxidase 4 (Gpx4) causes cell death in a pathologically relevant form of ferroptosis. Using inducible Gpx4(-/-) mice, we elucidate an essential role for the glutathione/Gpx4...    »
 
Zeitschriftentitel:
Nat Cell Biol 
Jahr:
2014 
Band / Volume:
16 
Heft / Issue:
12 
Seitenangaben Beitrag:
1180-91 
Sprache:
eng 
Print-ISSN:
1465-7392 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie