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Dokumenttyp:
journal article 
Autor(en):
Seubert, Bastian, B; Cui, Haissi, H; Simonavicius, Nicole, N; Honert, Katja, K; Schäfer, Sandra, S; Reuning, Ute, U; Heikenwalder, Mathias, M; Mari, Bernard, B; Krüger, Achim, A 
Titel:
Tetraspanin CD63 acts as a pro-metastatic factor via ?-catenin stabilization. 
Abstract:
The tetraspanin CD63 is implicated in pro-metastatic signaling pathways but, so far, it is unclear, how CD63 levels affect the tumor cell phenotype. Here, we investigated the effect of CD63 modulation in different metastatic tumor cell lines. In vitro, knock down of CD63 induced a more epithelial-like phenotype concomitant with increased E-cadherin expression, downregulation of its repressors Slug and Zeb1, and decreased N-cadherin. In addition, ?-catenin protein was markedly reduced, negatively...    »
 
Zeitschriftentitel:
Int J Cancer 
Jahr:
2014 
Sprache:
eng 
Print-ISSN:
0020-7136 
TUM Einrichtung:
r Virologie; Frauenklinik und Poliklinik