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Document type:
journal article 
Author(s):
Nehls, Julia; Koppensteiner, Herwig; Brack-Werner, Ruth; Floss, Thomas; Schindler, Michael 
Title:
HIV-1 replication in human immune cells is independent of TAR DNA binding protein 43 (TDP-43) expression. 
Abstract:
The TAR DNA binding protein (TDP-43) was originally identified as a host cell factor binding to the HIV-1 LTR and thereby suppressing HIV-1 transcription and gene expression (Ou et al., J.Virol. 1995, 69(6):3584). TDP-43 is a global regulator of transcription, can influence RNA metabolism in many different ways and is ubiquitously expressed. Thus, TDP-43 could be a major factor restricting HIV-1 replication at the level of LTR transcription and gene expression. These facts prompted us to revisit...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
e105478 
Language:
eng 
TUM Institution:
Institut für Virologie