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Dokumenttyp:
journal article 
Autor(en):
Tolosa, Eduardo; Litvan, Irene; Höglinger, Günter U; Burn, David; Lees, Andrew; Andrés, María V; Gómez-Carrillo, Belén; León, Teresa; Del Ser, Teodoro; TAUROS Investigators; Gómez, J C; Tijero, B; Berganzo, K; de Yebenes, J García; Lopez Sendón, J L; Garcia, G; Tolosa, E; Buongiorno, M T; Bargalló, N; Burguera, J A; Martinez, I; Ruiz-Martínez, J; Narrativel, I; Vivancos, F; Ybot, I; Aguilar, M; Quilez, P; Boada, M; Lafuente, A; Hernandez, I; López- Lozano, J J; Mata, M; Kupsch, A; Lipp, A; Ebers...    »
 
Titel:
A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy. 
Abstract:
It is believed that glycogen synthase kinase-3 (GSK-3) hyperphosphorylates tau protein in progressive supranuclear palsy (PSP). The Tau Restoration on PSP (TAUROS) study was a double-blind, placebo-controlled, randomized trial to assess the efficacy, safety, and tolerability of tideglusib, a GSK-3 inhibitor, as potential treatment for PSP. The study enrolled 146 PSP patients with mild-to-moderate disease who were randomized to receive once-daily 600 mg tideglusib, 800 mg tideglusib, or placebo (...    »
 
Zeitschriftentitel:
Mov Disord 
Jahr:
2014 
Band / Volume:
29 
Heft / Issue:
Seitenangaben Beitrag:
470-8 
Sprache:
eng 
Print-ISSN:
0885-3185 
TUM Einrichtung:
Neurologische Klinik und Poliklinik