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Dokumenttyp:
journal article 
Autor(en):
Ridder, Kirsten; Keller, Sascha; Dams, Maria; Rupp, Anne-Kathleen; Schlaudraff, Jessica; Turco, Domenico Del; Starmann, Julia; Macas, Jadranka; Karpova, Darja; Devraj, Kavi; Depboylu, Candan; Landfried, Britta; Arnold, Bernd; Plate, Karl H; Höglinger, Günter; Sültmann, Holger; Altevogt, Peter; Momma, Stefan 
Titel:
Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation. 
Abstract:
Mechanisms behind how the immune system signals to the brain in response to systemic inflammation are not fully understood. Transgenic mice expressing Cre recombinase specifically in the hematopoietic lineage in a Cre reporter background display recombination and marker gene expression in Purkinje neurons. Here we show that reportergene expression in neurons is caused by intercellular transfer of functional Cre recombinase messenger RNA from immune cells into neurons in the absence of cell fusio...    »
 
Zeitschriftentitel:
PLoS Biol 
Jahr:
2014 
Band / Volume:
12 
Heft / Issue:
Seitenangaben Beitrag:
e1001874 
Sprache:
eng 
Print-ISSN:
1544-9173 
TUM Einrichtung:
Neurologische Klinik und Poliklinik