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Document type:
journal article 
Author(s):
Specht, Katja; Sung, Yun-Shao; Zhang, Lei; Richter, Günther H S; Fletcher, Christopher D; Antonescu, Cristina R 
Title:
Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged ewing sarcomas: further evidence toward distinct pathologic entities. 
Abstract:
Round cell sarcomas harboring CIC-DUX4 fusions have recently been described as highly aggressive soft tissue tumors of children and young adults. Due to partial morphologic and immunohistochemical overlap with Ewing sarcoma (ES), CIC-DUX4-positive tumors have generally been classified as ES-like and managed similarly; however, a systematic comparison at the molecular and immunohistochemical levels between these two groups has not yet been conducted. Based on an initial observation that CIC-DUX4...    »
 
Journal title abbreviation:
Genes Chromosomes Cancer 
Year:
2014 
Journal volume:
53 
Journal issue:
Pages contribution:
622-33 
Language:
eng 
Print-ISSN:
1045-2257 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie; Kinderklinik und Poliklinik