In this thesis, lymphocyte memory was investigated by in vivo fate mapping of individual CD8+ T cells and their descendants across three generations of single cell adoptive transfer and infection-driven expansion. By this, we could conclusively demonstrate that propagation of antigen-specific T cell memory and reconstitution of immunocompetence can be achieved by individual CD62L+ central memory T cell (TCM). These observations establish for the first time that adult tissue stem cells reside within the TCM subset and build the basis for promising therapeutic applications.
«
In this thesis, lymphocyte memory was investigated by in vivo fate mapping of individual CD8+ T cells and their descendants across three generations of single cell adoptive transfer and infection-driven expansion. By this, we could conclusively demonstrate that propagation of antigen-specific T cell memory and reconstitution of immunocompetence can be achieved by individual CD62L+ central memory T cell (TCM). These observations establish for the first time that adult tissue stem cells reside wit...
»