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Document type:
journal article 
Author(s):
Gnirss, K; Fiedler, M; Kramer-Kuhl, A; Bolduan, S; Mittler, E; Becker, S; Schindler, M; Pohlmann, S 
Title:
Analysis of Determinants in Filovirus Glycoproteins Required for Tetherin Antagonism 
Abstract:
The host cell protein tetherin can restrict the release of enveloped viruses from infected cells. The HIV-1 protein Vpu counteracts tetherin by removing it from the site of viral budding, the plasma membrane, and this process depends on specific interactions between the transmembrane domains of Vpu and tetherin. In contrast, the glycoproteins (GPs) of two filoviruses, Ebola and Marburg virus, antagonize tetherin without reducing surface expression, and the domains in GP required for tetherin cou...    »
 
Journal title abbreviation:
Viruses-Basel 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
1654-1671 
Language:
eng 
Print-ISSN:
1999-4915 
TUM Institution:
Institut für Virologie