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Dokumenttyp:
journal article 
Autor(en):
Bonifacio, Ezio; Krumsiek, Jan; Winkler, Christiane; Theis, Fabian J; Ziegler, Anette-Gabriele 
Titel:
A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion. 
Abstract:
We recently developed a novel approach capable of identifying gene combinations to obtain maximal disease risk stratification. Type 1 diabetes has a preclinical phase including seroconversion to autoimmunity and subsequent progression to diabetes. Here, we applied our gene combination approach to identify combinations that contribute either to islet autoimmunity or to the progression from islet autoantibodies to diabetes onset. We examined 12 type 1 diabetes susceptibility genes (INS, ERBB3, PTP...    »
 
Zeitschriftentitel:
Acta Diabetol 
Jahr:
2014 
Band / Volume:
51 
Heft / Issue:
Seitenangaben Beitrag:
403-11 
Sprache:
eng 
Print-ISSN:
0940-5429 
TUM Einrichtung:
Kinderklinik und Poliklinik