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Author(s):
Grzmil, P.; Konietzko, J.; Boehm, D.; Hoelter, S. M.; Aguilar, A.; Javaheri, A.; Kalaydjiev, S.; Adler, T.; Bolle, I.; Adham, I.; Dixkens, C.; Wolf, S.; Fuchs, H.; Gailus-Durne, V.; Wurst, W.; Ollert, M.; Busch, D.; Schulz, H.; Hrabe de Angelis, M.; Burfeind, P. 
Title:
Targeted Disruption of the Mouse textitNpal3 Gene Leads to Deficits in Behavior, Increased IgE Levels, and Impaired Lung Function 
Abstract:
The non-imprinted in Prader-Willi/Angelman syndrome (NIPA) proteins are highly conserved receptors or transporters. Translocation of NIPA genes were found in patients with Prader-Willi syndrome, and loss-of-function of the NIPA1 gene was identified in hereditary spastic paraplegia. The family of NIPA-like domain containing (NPAL) proteins is closely related to the NIPA proteins, but to date nothing is known about their function. Here, we could demonstrate that both human NPAL3 and mouse Npal3 ar...    »
 
Keywords:
Atopic disease; Behavior; Immune system; <italic>Npal3 </italic>knockout mice; Phenotypic analyses 
Journal title:
Cytogenetic and Genome Research 
Year:
2009 
Journal volume:
125 
Journal issue:
Pages contribution:
186--200 
Fulltext / DOI:
Publisher:
S. Karger AG 
Publisher address:
Basel, Switzerland 
Print-ISSN:
1424-859X 
E-ISSN:
1424-859X 
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.