Benutzer: Gast  Login
Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Fricke, Elena; Hermannstädter, Christine; Keller, Gisela; Fuchs, Margit; Brunner, Ingrid; Busch, Raymonde; Höfler, Heinz; Becker, Karl-Friedrich; Luber, Birgit 
Titel:
Effect of Wild-Type and Mutant E-Cadherin on Cell Proliferation and Responsiveness to the Chemotherapeutic Agents Cisplatin, Etoposide, and 5-Fluorouracil 
Abstract:
Objectives: The cell adhesion molecule E-cadherin acts as a tumor and invasion suppressor and regulates cell proliferation. The aim of the present study was to investigate the impact of wild-type (wt) E-cadherin and tumor-derived mutant E-cadherin variants on the proliferation rate of MDA-MB-435S mammary carcinoma cells and the sensitivity of the cells to the chemotherapeutic drugs cisplatin, etoposide and 5-fluorouracil (5-FU) and whether p53 is involved in the chemotherapeutic response. Method...    »
 
Stichworte:
E-cadherin mutations; Cell growth; Chemosensitivity 
Zeitschriftentitel:
Oncology 
Jahr:
2004 
Band / Volume:
66 
Heft / Issue:
Seitenangaben Beitrag:
150--159 
Verlag / Institution:
S. Karger AG 
Verlagsort:
Basel, Switzerland 
Print-ISSN:
1423-0232 
E-ISSN:
1423-0232 
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.