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Autor(en):
Golda, Adam; Pelisek, Jaroslav; Klocke, Rainer; Engelmann, Markus G.; Rolland, Pierre-Henri; Mekkaoui, Choukri; Nikol, Sigrid 
Titel:
Small Poly-textitL-Lysines Improve Cationic Lipid-Mediated Gene Transfer in Vascular Cells in vitro and in vivo 
Abstract:
The potential of two small poly-L-lysines (sPLLs), low molecular weight sPLL (LMW-L) containing 7–30 lysine residues and L18 with 18 lysine repeats, to enhance the efficiency of liposome-mediated gene transfer (GT) with cationic lipid DOCSPER [1,3-dioleoyloxy-2-(N5-carbamoyl-spermine)-propane] in vascular smooth muscle cells (SMCs) was investigated. Dynamic light scattering was used for determination of particle size. Confocal microscopy was applied for colocalization studies of sPLLs and plasmi...    »
 
Stichworte:
Gene transfer; Lipopolyplexes; Poly-<italic>L</italic>-lysine; Cationic lipid; Smooth muscle cells 
Zeitschriftentitel:
Journal of Vascular Research 
Jahr:
2007 
Band / Volume:
44 
Heft / Issue:
Seitenangaben Beitrag:
273--282 
Verlag / Institution:
S. Karger AG 
Verlagsort:
Basel, Switzerland 
Print-ISSN:
1423-0135 
E-ISSN:
1423-0135 
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.